
A cross-sectional study of PPMI participants using alpha-synuclein seed amplification as a biomarker
MDS Podcast
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The Effects of Parking on the SAA
The key take-home is that MSA produces a maximal fluorescence which is sort of intermediate between negative and the PDP fluorescence. And we know that in LART2 cases usually you don't have Lewy pathology and you saw lower assay positivity so that seems to fit. Given what we know about Lewy body pathology in parking cases at the moment, would you expect also a lower signal in the SAA in parking cases? Can you make any predictions? Yes, I think there's an occasional positive case but the majority, maybe 80 percent are negative.
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