Big Biology Episodes - Episode 5 - Dr Dan Gibbs

What is the free energy principle? How do our brains use active inference to manage uncertainty and stress?

On this episode, we talk with Karl Friston, world-renowned neuroscientist at University College London, about his free energy principle. In order for the human brain or any other self-evidencing system (be it Earthly or alien) to exist, they must be able to make inferences about their environments, and adjust their internal models of the world to resist entropy. In the show, we discuss how Karl’s previous work as a psychiatrist led him to this theory, then take a deep dive into the free energy principle, discussing how it can help us understand stress, agency, DNA, and the possibility of life elsewhere in the universe.

Cover art: Keating Shahmehri