23min chapter

The Immunology Podcast cover image

Ep. 3: “Platelets and the Immune System” Featuring Dr. Bernardo Franklin

The Immunology Podcast

CHAPTER

Understanding Immune Responses to Coronaviruses and Cancer: The Role of T Cells

The chapter explores the interplay of CD8 T-cells specific to an immunodominant SARS-CoV-2 epitope and their cross-reactivity with seasonal coronaviruses. It discusses protein structure, immunodominance within HLA subtypes, and the implications of identified epitopes on immune responses and COVID heterogeneity. Additionally, it delves into gamma delta T cells' function in immune responses, particularly in cancer immunotherapy and the potential synergistic effects of combining DNA methyl transferase inhibitors with gamma delta T cells.

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