Humanin | The Mitochondrial Peptide for Brain Health and Longevity
The Hunter Williams Podcast
Cellular mechanisms and anti-apoptotic action
Hunter outlines Humanin's signaling (JAK/STAT, ERK, PI3K/AKT) and its binding to pro-apoptotic proteins to prevent cell death.
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In today’s episode, I’m diving into a mitochondrial peptide that almost nobody is talking about yet, but that I believe is going to become a major player in longevity and brain health over the next decade: Humanin.
Most people are familiar with mitochondrial peptides like SS-31 or MOTS-c. Humanin is different. It’s an endogenous mitochondrial-derived peptide, meaning your body actually makes it naturally, and it plays a critical role in protecting cells, especially under conditions of stress and aging. What really caught my attention with Humanin is that it appears to sit at the intersection of mitochondrial health, neuroprotection, and longevity signaling.
In this episode, I walk through what Humanin is, how it was discovered, and why researchers originally became interested in it, particularly in the context of Alzheimer’s disease and neurodegeneration. We’ll talk about how Humanin functions as a cellular “distress signal” from the mitochondria, how it blocks apoptosis, protects mitochondrial membranes, and helps cells survive oxidative and metabolic stress.
I also break down how Humanin differs from other mitochondrial peptides like MOTS-c and SS-31, and why I see it as a uniquely powerful option for brain health and cognitive longevity. We’ll look at animal data, observational human data, and fascinating correlations showing that centenarians and their offspring tend to have significantly higher endogenous Humanin levels.
From there, I cover potential benefits across brain health, metabolism, cardiovascular function, and lifespan, along with how I personally think about cycling Humanin alongside other mitochondrial peptides throughout the year. Finally, I share my practical thoughts on dosing, cycling strategies, and who I think Humanin is best suited for, especially as we get more focused on preserving cognitive function as we age.
If you’re interested in mitochondrial health, longevity, brain optimization, or peptide replacement strategies, this episode will give you a solid foundation on why Humanin deserves a spot on your radar.
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