The Importance of Reducing Dose

May, just before you get into pitour, just what you said about the importance of reducing dose. And just mention something which is not much known. The diamond trial was a trial that was just recently published in European Heart Journal. It was a trial of over 800 patients who had an open label run where they were required to take high doses of sprunal actone and a player known and higher doses of conventional renin angiotensin system inhibitors.