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#274 – Karl Deisseroth: Depression, Schizophrenia, and Psychiatry
Lex Fridman Podcast
What's the Unifying Principle in Depression?
In a mouse, for example, we can instantaneously and precisely turn up or down the motivation of an animal to overcome a challenge. But we don't know is why all these different symptoms show up together in major depression in the human disease syndrome. And that's, that's the mystery. It's sort of in other fields of medicine, you know, someone with congestive heart failure who comes into the clinic - they have very different symptoms. They have shortness of breath and they have swollen feet. Couldn't be too more different sets of symptoms. Neither one obviously related to the heart, but they're both happening because the heart is not working as a pump. Okay. That
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