Hemoglobin A1C - Is There Nuance Thinking Required?

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About This Episode:

Often claims are made recommending that people should aim to keep peaks in blood glucose low in terms of both magnitude and frequency.

And while many claims about blood glucose “spikes” are incorrect or purposefully exaggerated to grab attention, there are some reasonable and interesting hypotheses put forward in relation to blood glucose variability and excursions.

For example, interesting questions have been raised in relation to the impact of blood glucose excursions in seemingly normoglycemic and/or healthy people.

In this episode, we look at three specific elements of this: average blood glucose, glucose variability, and glucose peaks. All in the context of people without prediabetes or type diabetes, who have typical blood glucose measures in the ‘normal’ range.

Specifically, we look at three hypothesized recommendations made elsewhere:

1. “The lower you average blood glucose (HbA1C) is better, even if already in normal range”
2. “The more you can minimize glucose variability, the better.”
3. “Minimizing the number of glucose “peaks” is important, even if they don’t meet the threshold for hyperglycemia”

Can normoglycemic people benefit from further reducing these measures? Let’s take a look…