Introduction

Kirsten Bibbins-Domingo: This is the JAMA Editor's Summary, a review of important research and review articles appearing in the latest JAMA issue. The first article is from Dr. Nagian colleagues investigating the effect of a higher dose of Ivermectin versus placebo on time to sustained recovery in outpatients with COVID-19. Doctors London and Seymour provide an accompanying editorial on the ethics of clinical research and managing persistent uncertainty.