The Effect of Irreversible Hack on PSI Patients

The majority of these patients were established disease as you say sort of six to eight years of disease before they'd come into the trial. Most of them had been through other drugs before some of them were biologic experienced. So there's quite a lot of disease in different areas of different domains of psoriatic arthritis that's active for these patients coming through. I wonder if similar to the rheumatoid experience given those details there'll be an element irreversible hack do you think that's a real thing in PSI patients? Yeah definitely so we've looked at the hack obviously hack is very responsive in these studies but getting down to low levels is not always possible.