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The Power of the Negative Study

ACR Journals On Air

CHAPTER

Measurement of Anti-Drug Antibodies and Impact on Half-Life

This chapter discusses the potential measurement of anti-drug antibodies in future studies and how they can affect the half-life of monoclonal antibodies. The presence of anti-drug antibodies in patients was observed in this trial, but its impact on pharmacokinetics was unclear due to a small sample size.

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