TWiV 954: Speculating sarbecovirus spillovers with Michael Letko
This Week in Virology
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Can Tripsin Conditions Support Multiple Cycles of Replication?
The study is looking at this ACE2 independent, Tripsin dependent entry that we talk about. And so I collaborated with WIV over the past year now to test recombinant coronaviruses. The conditions that we outline in the first paper actually do support some of these clade to serbico viruses that have double deletions. So really showing the conditions needed for this group of viruses to replicate.
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