5min chapter

The Proof with Simon Hill cover image

Can We Cure Aging?: Unpacking the Interventions | Andrew Steele, PhD

The Proof with Simon Hill

CHAPTER

The Effect of Yamanacophactors on Mouse Health

In the 2010s people are starting to put these genes into mice and see what happens. If you start inducing this pluripotency throughout the body you're going to get massive organ failure so it's really bad news to turn these things on all the time. However an experiment a few years later tried they they coupled the gene with something that meant they were only actually turned on when a particular drug was given to the mice. They found that by giving these yamanacophactors transiently rather than on all of the time they did seem to be able to improve mouse health. Now we've got more experiments we've had we've shown that you can actually extend the lifespan of normal

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