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Has the evidence on probiotics finally reached a tipping point? On this Journal Club, Ben, fresh off a night shift, opens with two announcements: a follow-up on the ABP’s fellowship length decision and a new partnership with Pediatrix that may finally bring CME to the platform. Daphna highlights the Neonatal Insights conference in Houston. Ben then reviews a Swedish national cohort of nearly 4,700 infants born at 28 to 31 weeks, where a three-strain probiotic was linked to a 72% lower risk of death or NEC and near elimination of surgical NEC. He places the findings alongside recent Dutch and US studies, discusses Ravi Patel’s editorial on immortal time bias, and asks where the probiotic evidence truly lands.
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Probiotics and Risk of Death, Necrotizing Enterocolitis, and Sepsis in Very Preterm Infants. Mitha A, Söderquist Kruth S, Sinervo E, Domellöf M, Brindefalk B, Abrahamsson T, Johansson S, Rakow A.JAMA Netw Open. 2026 Sep 1;9(9):e2635560. doi: 10.1001/jamanetworkopen.2026.35560.PMID: 42776528 Free PMC article.
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