In this episode we discuss:
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How glucose and insulin decrease glycation
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Why ketogenic diets can be worse than high-carb diets when it comes to AGE formation
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How autophagy helps to clear AGEs, but increasing autophagy is not the answer
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The true primary drivers of AGE accumulation
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The best diet and supplements for minimizing glycation
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
Click here to check out the show notes:
https://www.jayfeldmanwellness.com/eb-138-low-carb-diets-increase-glycation-and-what-to-do-instead/
Timestamps:
0:00 – intro
0:57 – how glycation products are detoxified and cleared from the body
4:03 – glycation detoxification is impaired by oxidative stress and inflammation, as seen in type 2 diabetes
7:56 – the benefits of carbohydrates for the detoxification of glycation products
10:42 – the benefits of insulin for the detoxification of glycation products
12:45 – how AGEs are cleared
14:36 – increasing autophagy via hormesis is not the answer for clearing AGEs
19:09 – autophagy can drive disease
20:50 – ATP protects against oxidative stress and allows for proper autophagy when needed
24:37 – impaired mitochondrial along with fatty acid oxidation impairs autophagy and increases oxidative stress
26:54 – carbohydrates do NOT inhibit autophagy
29:18 – adequate thyroid hormone supports proper autophagy
30:15 – adequate ATP and mitochondrial function is needed for the UPS (ubiquitin proteasome system)
32:56 – do high-carb diets actually impair metabolism and insulin sensitivity
35:26 – is fructose really worse for blood sugar regulation and glycation?
37:16 – are low-carb or ketogenic diets the solution to reduce glycation?
40:32 – increased glycation and oxidative stress on ketogenic diets
44:09 –low-carb diets don’t prevent glucose exposure
47:56 – there are still considerable insulin and glucose excursions on low-carb diets
50:06 – gluconeogenesis leads to same glycolytic intermediates as glucose metabolism
51:52 –the main driver of AGE formation and impaired AGE clearance
53:40 – the role of vitamin B1 (thiamine) and mitochondrial energy production in decreasing AGEs
56:27 –endotoxin as a driver of glycation and increased AGE production
58:12 – hypothyroidism as a driver of glycation and AGE accumulation
59:37 – dietary solutions for reducing glycation and AGEs
1:03:33 – how to support the glyoxalase pathway to support the detoxification of glycation products
1:05:56 – avoid calorie restriction, low-carb diets, fasting, resveratrol, cold exposure, excess exercise, and iron overload to decrease glycation and AGEs
1:07:33 – iron as a double-edged sword for oxidative stress
