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Dr. David Anderson: The Biology of Aggression, Mating, & Arousal

Huberman Lab

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The Switchboard of Instincts: PAG and Tachykinin

This chapter explores the intricate role of the periaqueductal gray (PAG) in behaviors such as pain modulation and aggression, likening its function to a switchboard for instinctual signals. It delves into tachykinins, neuropeptides vital to social behavior and pain processing, and discusses their evolutionary implications across species. Additionally, the chapter addresses the challenges of translating animal research into human clinical trials, particularly during the COVID-19 pandemic.

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