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#533 - Matthew Cobb - Should We Genetically Edit Human Life?
Modern Wisdom
CRISPR Gene Drive
In certain microbes, there exists a parasitic bit of DNA that produces an enzyme that will cut very precisely at a location of the genome. So what happens is that you've got one copy of this gene. It's expressed, it produces an enzyme, and it chops the DNA on the other chromosome. In the next generation, that individual mates with an ordinary individual. Can you imagine that on a population scale? And basically, you've got exponential growth. If one of these things were to get out, then even a single individual, assuming it survived, and made it after one or two generations, this would then go haywire. There'd been no way of stopping it.
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