Metformin-Associated Lactic Acidosis

Joel: It sounds like we historically have been wary of those numbers because it had not been studied, not because there was some sort of catastrophic outcome that had occurred with them. And now we've actually had trials that have started a little bit lower. David: But the point about metformin totally valid and also very important to this discussion. Joel: Now that we're more comfortable using the SGLT2s at that lower EGFR, even when they drop below 20, you’re saying you would initiate,. even if they're above 20, like their EGFR 22, you would initiate it. What if they, six months later are down to an EGFR 15