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Ketamine: Benefits and Risks for Depression, PTSD & Neuroplasticity
Huberman Lab
The Effects of Ketamine on Depression
Ketamine has this incredible property. It can literally change the neural circuits that generate mood, that generate your feelings of well-being. But it does so through a somewhat convoluted pathway,. It blocks the receptor that everyone thinks is involved in neuroplasticity. The process I just described of how ketamine creates neuroplasticy through blockade of NMDA receptors is very likely to be the process that explains the longer-term changes in mood and affect associated with ketamine therapy for depression.
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