
How I Treat Series: Emergent CAR T-Cell Toxicities
Blood Podcast
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The Role of Expression Profiles in Toxicity Prediction
As a new clinical trials are launched it is important to carefully evaluate the expression profile of novel targets. For instance in the manuscripts we described the BCMA dependent toxicity in the Basel Ganglia which may lead to some cases of Parkinsonism. A very successful most recent trial targeting a molecule called the GPRC 5D in multiple myeloma that in rare cases led to unusual cerebellar toxicities because these molecules also expressed in the medulla oblongata and so this could be one takeaway.
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