Blood Podcast cover image

How I Treat Series: Emergent CAR T-Cell Toxicities

Blood Podcast

00:00

The Role of Expression Profiles in Toxicity Prediction

As a new clinical trials are launched it is important to carefully evaluate the expression profile of novel targets. For instance in the manuscripts we described the BCMA dependent toxicity in the Basel Ganglia which may lead to some cases of Parkinsonism. A very successful most recent trial targeting a molecule called the GPRC 5D in multiple myeloma that in rare cases led to unusual cerebellar toxicities because these molecules also expressed in the medulla oblongata and so this could be one takeaway.

Transcript
Play full episode

The AI-powered Podcast Player

Save insights by tapping your headphones, chat with episodes, discover the best highlights - and more!
App store bannerPlay store banner
Get the app