TWiV 1206: Clinical update with Dr. Daniel Griffin
This Week in Virology
Evaluating Vaccines and Treatments for COVID-19
This chapter reviews a preprint study on the mRNA-1273 vaccine's effectiveness against the KP2 variant, highlighting its significant reduction in hospitalization rates. It also discusses the urgent need for flu vaccinations and explores research on metformin's impact in diabetic patients with COVID-19. The conversation emphasizes the complexities of treatment options and reinforces the critical role of vaccinations to mitigate severe outcomes.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello lament about the continuing measles outbreak, whether or not the measles outbreak was predicted, the FACTS about vaccination, high pathogenic influenza, H5N1 contaminated raw pet food, children’s deaths, before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections and vaccination schedules and the efficacy of Moderna’s seasonal mRNA vaccine, societal burden of COVID-19 and influenza, the FDA missed deadline for approving Novovax COVID vaccine, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, long COVID interventions, and Canada’s long COVID dashboard.
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Links for this episode- CDC buried a measles forecast that stressed the need for vaccinations….TRANSPARENCY? (Politico)
- Measles cases and outbreaks (CDC Rubeola)
- Measles 159 in Texas…. (Texas Health and Human Services)
- 2025 Measles outbreak guidance (New Mexico Health)
- Measles and rubella weekly monitoring report (Government of Canada)
- Enhanced epidemiological summary Measles in Ontario (Public Health Ontario)
- Measles and rubella weekly monitoring report (Government of Canada)
- Enhanced epidemiological summary Measles in Ontario (Public Health Ontario)
- Measles exposures in Ontario (Public Health Ontario)
- Measles vaccine recommendations from NYP (jpg)
- Get the FACTS about measles (NY State Department of Health)
- Measles (CDC Measles (Rubeola))
- Measles vaccine (CDC Measles (Rubeola))
- Presumptive evidence of measles immunity (CDC)
- Contraindications and precautions to measles vaccination (CDC)
- Measles (CDC Measles (Rubeola))
- Raw cat food tests positive for H5N1 (CIDRAP)
- Influenza: Waste water scan for 11 pathogens WastewaterSCan)
- US respiratory virus activity (CDC Respiratory Illnesses)
- Weekly surveillance report: clift notes (CDC FluView)
- Respiratory virus activity levels (CDC Respiratory Illnesses)
- FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA)
- RSV: Waste water scan for 11 pathogens (WastewaterSCan)
- US respiratory virus activity (CDC Respiratory Illnesses)
- RSV-Network (CDC Respiratory Syncytial virus Infection)
- Early impact of RSV vaccination in older adults in England (Lancet)
- Waste water scan for 11 pathogens (WastewaterSCan)
- COVID-19 deaths (CDC)
- COVID-19 national and regional trends (CDC)
- COVID-19 variant tracker (CDC)
- SARS-CoV-2 genomes galore (Nextstrain)
- Evaluating the effectiveness of 2024-2025 seasonal mRNA-1273 vaccination against covid-19-associated hospitalizations and medically attended covid-19 among adults aged ≥ 18 years in the united states(medRxiv)
- Current Moderna vaccine 53% effective against COVID hospitalization?(CIDRAP)
- Preliminary estimates of COVID-19 burden for 2024-2025 (CDC COVID-19)
- Estimated range of annual burden of flu in the US from 2010 – 2024 (CDC-flu burden)
- US FDA missed the deadline for decision on Novavax’s COVID-19 vaccine (Reuters)
- Interim clinical considerations for use of COVID-19 vaccines in the United States (CDC Vaccines & Immunizations)
- Where to get pemgarda (Pemgarda)
- EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
- Fusion center (Prime Fusions)
- CDC Quarantine guidelines (CDC)
- NIH COVID-19 treatment guidelines (NIH)
- Metformin alleviates inflammatory response and severity rate of COVID-19 infection in elderly individuals(Scientific Reports)
- Drug interaction checker (University of Liverpool)
- Infectious Disease Society guidelines for treatment and management (ID Society)
- Cost-effectiveness analysis of nirmatrelvir/ritonavir for high-risk individuals with COVID-19….does this mean use the big button calculator? (OFID)
- Molnupiravir safety and efficacy (JMV)
- Convalescent plasma recommendation for immunocompromised (ID Society)
- What to do when sick with a respiratory virus (CDC)
- When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC
- Managing healthcare staffing shortages (CDC)
- Steroids, dexamethasone at the right time (OFID)
- Anticoagulation guidelines (hematology.org)
- Daniel Griffin’s evidence based medical practices for long COVID (OFID)
- Long COVID hotline (Columbia : Columbia University Irving Medical Center)
- The answers: Long COVID
- Reinfection with SARS-CoV-2 in the omicron era is associated with increased risk of post-acute sequelae of SARS-CoV-2 infection: a recover-EHR cohort study(medRxiv)
- CAN-PCC RecMap, your one-stop shop for recommendations about Post COVID-19 Condition (Long COVID) (Canadian Guidelines for post COVID-19 condition)
- Letters read on TWiV 1206
- Dr. Griffin’s COVID treatment summary (pdf)
- Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
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