#05 Matt Kaeberlein | Aging Interventions - Rapamycin, mTOR, CR, Sirtuins, NAD+ & Dog Aging Project
Live Longer World
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What's the Risk-Reward Ratio of Sirtuans?
Sirtuan is a family of enzymes that are all related to the yeast sirtuan that we overexpressed and extended lifespan. There's one paper now showing that if you overexpress the mouse version of sirtu, which is called sirtu 1, you can get a small effect on lifespan. Is it important? I don't know my view on sirti 1 is it is effective as an aging target. So there are seven of them in mammals; at least in mammals, there are five or six for humans. And they're unique in the sense that they have what are called NAD-dependent deacetylases. They use NAD, which is a co
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