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The Lymphoma Sessions: ASH 2020 highlights

VJHemOnc Podcast

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CNS Prophylaxis in Diffuse Large B-cell Lymphoma

This chapter discusses the efficacy of intravenous high-dose methotrexate as CNS prophylaxis in diffuse large B-cell lymphoma, highlighting two retrospective analyses that found no reduction in CNS relapse rate. The ongoing debate around CNS prophylaxis and the speaker's cautious approach, particularly in patients over 70, is also mentioned. The chapter further explores reactions to recent research, the significance of dose intensity in R-Chop treatment, and the need for international collaboration in T-cell lymphoma trials.

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