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Ep. 65: “Primary Immunodeficiency Disorders” Featuring Dr. Siobhan Burns

The Immunology Podcast

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Discovery of a Unique Peptide and its Binding to Noncanonical MHC Molecule

This chapter explores a study that investigates the presentation of a viral antigen on a noncanonical MHC molecule called QA1 in mice. The researchers conduct an immunopedidomic analysis using a common influenza strain, leading to the discovery of a unique nine amino acid peptide called MSL9. They discuss its activation of CD8 cells and its binding to a noncanonical MHC class I B molecule, along with the biochemistry behind it.

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