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Reason | Q&A on How to Fight Aging
The Foresight Institute Podcast
The Role of LDL Cholesterol in Mortality
Atherosclerosis is basically the encounter of an aged macrophage with cholesterol, at which point you get a lot of cell death and cholesterol based plaque. Normal macrophages can't do anything with excess cholesterol. If you overwhelm their existing systems for trying to get rid of it by handing it off to HDL particles, you're done. There's no way for it to inherently deal with this degree of cholesterol.
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