2min chapter

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Chapter Eleven, part 2: Regulation of Acid-Base Balance

Channel Your Enthusiasm

CHAPTER

The Mechanism of Cell Shift in Proximal Tumor Cells

When you have hypokalemia, then you would like to not lose any more potassium. And so if you can rev up ammonia genesis, then you'll have more ammonia excretion distally rather than k-loss. So I think that it may be because of that shift in the proximal tubular cells, but by design. Because perhaps potassium is more important than pH in this instance. By having that extra ammonium made, now you have more available to bind hydrogen and then less k- loss.

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