Understanding Muscle Protein Synthesis and Training Frequency

In this debut episode, Jake Doleschal and Chris Beardsley dissect the very first mass-produced bodybuilding program: the Milo Barbell Course. They explore how early bodybuilders trained before steroids existed and what their exercise choices reveal about muscle understanding. They then connect these historical methods to modern muscle physiology, focusing on the stimulating reps model and the critical role of training frequency. You'll learn why full-body training 3x per week was not just a product of the time, but may still be the optimal approach for natural hypertrophy today.

Key topics:

• What the Milo Barbell Course included (and what it left out)
• How pre-steroid era training evolved
• How early lifters intuitively selected exercises based on regional hypertrophy
• Why high-frequency training (e.g. 3x per week) is physiologically superior (even without factoring in atrophy!)
• The nonlinear dose-response of training volume: why first sets matter most