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The Life and Times of Holmes
In 1884, Holmes was in some serious trouble. He had to defend himself before the medical faculty after being charged with breach of promise. At this point, maybe he had plans to murder and defraud on like a galactic scale later. But I think it was more that this was kind of the training along with the whole chemistry obsession. This is all the stuff that just kind of like slowly put the pieces together for him to become that later.