Episode 180: Keywords part 12 with Gillian Isaac: Local Anesthetics
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
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Lipit Solubility and Local Anesthetic Potency
The primary determinete of local anesthetic potency is a, p, a, b, molecular weight, c, lietsiability, depots in bindning exactly. You'll probably see that lippits ibility will e. The key point this clinical use of local anaesthetics may be increased by addition of epinefin, o pioits and alpha to agenags agonists. It's debatable, im but this is a question that you might see. We used to add by hard t alkalis to have more non ionized local so across the possible membrand quicker. But it's something we got away from ther're literaly like a thousand studies on this
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