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Getting to the Bottom of My Health: Biotin and (V)LCAD

Mastering Nutrition

CHAPTER

The Effects of Acyl-CoA Profiles on Metabolic Function

CoA starvation will, if it is not resolved, cause an abrupt halt to all metabolism. Since this would result in death, the block must be resolved. Small acids such as propionic acid or methylmalonic acid are similar enough in size that their CoA esters resemble a single CoA and act as an imposter of asingle CoA. In order to resolve this, carnitine and glycine are used to free the CoA by acting as alternative carriers. Thus, acyl-CoA's become free CoA and acyl-carnitines or acyl-glyceins. These ultimately are needed to get the acyl groups out of the cell

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