The Effects of Fluid Bolus on Cardiovascular Collapse

We screened almost 1,600 critically ill adults undergoing tracheal intubation in a participating unit and enrolled approximately or excluded about 500 of those. The most common reason for exclusion was that the procedure was too emergent for trial procedures to be safely performed. Most characteristics across the two groups were well matched. Patients randomized to fluid bolus received a 500 milliliter crystalloid fluid bolus initiated prior to induction 99% of the time. Whereas patients randomized to the no fluid bolus arm did not receive a new fluid bolus between enrollment and induction 99%.