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Chapter Nine: Regulation of Plasma Osmolality

Channel Your Enthusiasm

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Is There a Half Life of ADH?

The ADH has a half life. Your peak diuresis will be 90 to 120 minutes following your water load because you need to metabolize the pre existing ADH. So I was thinking about that and, you know, I've got non-nephrologist friends that talk about exact phenomena when they go out drinking and they have a term for this. They call it breaking the seal. And then once you start, you're heading to the bathroom all the time.

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