Are You Sure That Your Findings Are Reproducible?

In fields ranging from psychology through to cancer biology, about 40% of findings are reproducible. How often should this happen, in your opinion? We don't really know what the optimal rate of reproducibility should be. My personal feeling is that where it seems to be at the moment is probably too low. But there perhaps needs to be just a piece of work done or a bit of thought put into exactly what that optimal tradeoff is.