Brain organoids have become increasingly intricate since they were first created in 20 13 by madeline lancaster and jugen kneblich. De pawles team did the same transplant experiments using nurons made from cells from people with down sindrome. They found that these nurons formed less dynamic networks with lower neural activity. Neither team has tested cognition or behavior in the transplanted mice but all report that the mice generally behaved like ther non transplanted peers.

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