The Limitations of the Trial

The overall outcomes of patients they're quite comparable to raising congenital heart disease reports you know for example with more challenge of about 1.3 percent. Despite these brain there are a number of limitations that are important to consider so first of all it was no dollars finding trial and we cannot comment on a potential different effect associated with different doses. We did not investigate the biology of of nitric oxide the living of bypass the perfusion is to were not blinded as the only team members that were not done. There was a very small use of inhaled nitric oxide in pro-bose study arms. The choice ventilator three days as a primary endpoint we chose it because it is objective