Decoding COVID-19 Vaccine Efficacy

TWiV explains a cohort study of over one million Danish children which shows no evidence supporting an increased risk for autoimmune, atopic or allergic, or neurodevelopmental disorders associated with early childhood exposure to vaccines with aluminum-base adjuvants, and a study of antibodies induced by mRNA-1273 and NVX-CoV2373 COVID-19 vaccines which show that polyclonal antibodies against a single site on the spike N-terminal domain show immunodominance, high diversity, and limited cross-reactivity, indicating the need to direct antibody responses away from this site.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

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• Support science education at MicrobeTV
• No chronic effects of aluminum-based adjuvants in vaccines (Ann Int Med)
• Aluminum in vaccines (CHOP)
• Structural serology of antibody responses to COVID vaccines (Cell Rep)
• Letters read on TWiV 1239
• Timestamps by Jolene Ramsey. Thanks!

Brianne – MHC Class I Antigen Presentation Video Alan – We Become What We Behold Vincent – New Injectable Recommended by Europe for HIV Prevention

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.