There is something called a imprinting or original antogenic sin. The one side effect that came sort of unanticipated and has really implications, i think, for safe vaccination. It might be theoretically possible that the fact somebody has gotten more boosters of the original strain makes their response stimulate anti bodies to the original spike protein epitopes,. So that's a potential theoretical downside. Other countries have rates of myro carnitus that are non trivial after dose two of the fiser vaccine. This is a serious adverse event. And it often leads people to come into the hospital a they always say, it's mostly mild, ok, but may not.