You’ve surely seen the hyped news stories. Psychedelic drugs are no longer just for hippies and attendees at raves: they’re the new frontier of mental health treatment, revolutionising how we think about conditions like depression and PTSD and showing major promise in clinical trials.

In this episode of The Studies Show, Tom and Stuart look into psychedelics and mental illness. They start by talking about why scientists think psychedelics might be relevant here - and it’s to do with the theory of the “Bayesian Brain”. Then they get into the studies, and point to some serious hurdles on the way to getting good evidence on this question.

The Studies Show is sponsored by Works in Progress magazine, the best place to find insightful essays on science, technology, and human progress. We’re very grateful for their support.

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Show Notes

* Announcement that Australia has legalised psychedelics for some kinds of psychotherapy

* A long, highly technical exposition of the Bayesian Brain theory with reference to psychedelics

* Criticism of the Bayesian Brain theory more generally

* Stuart’s Substack post on psychedelics

* The Phase II randomised trial of psilocybin versus escitalopram

* The Phase III randomised trial of MDMA for PTSD

* The New York Magazine podcast series raising some safety concerns about psychedelic therapy

* Eiko Fried’s Twitter thread on a very bad study of psychedelics and mental illness

Credits

The Studies Show is produced by Julian Mayers at Yada Yada Productions.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit sciencefictionspod.substack.com/subscribe

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