4min chapter

Febrile cover image

59: Hide & Seq: An ID Fellow Primer on Molecular Diagnostics

Febrile

CHAPTER

Sequencing for Detection of Pathogens

Next generation sequencing on amplified single genes like the 16 S ribosomal RNA gene that we just talked about which is more of a targeted metagenomic approach. Another is CSF next-gen sequencing for meningitis and encephalitis. This is a category where we've never been able to chip away at that 50% of suspected cases of CNS infectionthat we just can't get a microbial diagnosis.

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