It's a good idea not to let the visual presentation and the kind of code level stray too far from each other if you can help it. You have to give some care and thought to the order content appears for everybody, whether you're looking at it, tabbing through it with a keyboard and still looking at it or like me listening to it just through speech. Three or four percent of people who use screen readers can see perfectly well. They use them because they have cognitive disabilities and listening to content is a lot less full of distractions than looking at the web can be.