I Won't Make It Girls, I'm Going to Manchester, My Boyfriend

She has been very vocal in the last year about me and my friend's single lifestyle. Her comments have come from a place of insecurity as she is a relationship person. Now reaching the point where it's nasty and the comments are now starting to hurt her feelings. My dilemma is because I know she has been struggling and is clearly lost within herself at the moment. Am I wrong if I was to tell her that she is being nasty? Or am I just expected to basically sit back and let her make mean comments purely because she's struggling? She will go straight into denial and deny all these things I say. The other two girls in our group feel the same and have also distanced themselves