In-depth Analysis of Treatment Options for Locally Advanced and Metastatic Rectal Cancer

Exploring the efficacy of immunotherapy in treating locally advanced rectal cancers with deficient MMR or MSI high status, including insights from a phase two trial and recommendations for treatment duration. Comparisons between metastatic rectal and colon cancer treatments, emphasizing next-generation sequencing, chemotherapy choices, and potential resection options for liver or lung metastases with targeted therapies.