Half-lives and Dosing Frequency

Expert physician researcher Sunil Wimalawansa explains why Vitamin D plays a critical role in immune system function, the physiology various forms of vitamin D and how to ensure you keep a level compatible with optimal health.

Dr Sunil J. Wimalawansa, MD, PhD is a globally respected clinician-scientist, educator, over three decades of leadership in endocrinology, osteoporosis, metabolic bone disease, and nutrition. He served as professor and chief of endocrinology at leading U.S. medical institutions, including the Robert Wood Johnson Medical School/Rutgers University.

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TIMESTAMPS
3:30 Vitamin D Metabolism Made Clear
9:30 Sunlight Timing And Skin Production
15:20 Peripheral Activation And Inactivation
21:40 Immune Cells Depend On Daily Supply
27:00 D3 vs Calcifediol vs Calcitriol
33:20 Acute Illness, ICU, And Rapid Repletion
39:30 Safety, Toxicity, And Hypercalcemia
45:10 Disease Thresholds And Target Levels
51:30 MS, Autoimmunity, And Latitude Clues
58:00 Dosing Rules And Obesity Adjustments
1:04:00 Frequency Matters More Than Mega Doses
1:09:00 K2, Magnesium, And Cofactors
1:14:00 Study Design Pitfalls And Bias
1:21:00 Practical Takeaways And Resources

REFERENCED PAPERS

Calcifediol Treatment and Hospital Mortality Due to COVID-19: A Cohort Study PMID: 34064175 https://pubmed.ncbi.nlm.nih.gov/34064175/

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DISCLAIMER: The content in this podcast is purely for informational purposes and is not a substitute for professional medical advice, diagnosis, or treatment. Do not disregard professional m

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