In this episode we discuss:
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How the Randle Cycle actually works
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Whether eating carbs and fats in the same meal causes weight gain and insulin resistance
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The efficiency of using fats as a fuel vs carbohydrate
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How stress impacts fuel usage in the mitochondria
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How to determine the optimal amount of carbs and fats in your diet
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
Click here to check out the show notes:
https://www.jayfeldmanwellness.com/eb-139-the-truth-about-the-randle-cycle-why-you-can-eat-carbs-and-fats-together/
Timestamps:
0:00 – intro
0:53 – misconceptions regarding the Randle cycle in the alternative health world
4:57 – what is the Randle cycle?
7:06 – what most people get wrong about the Randle cycle
10:44 – fat oxidation leads to increased ROS production and a decreased NAD+/NADH ratio
16:29 – how fat oxidation inhibits the utilization of carbohydrates
21:03 – the Randle cycle shows the benefits of burning carbs for energy
25:56 – how fat oxidation inhibits the utilization of carbohydrates cont’d
26:57 – metabolic dysfunction, not glucose, drives insulin resistance and aging
32:07 – fat metabolism causes a buildup of citrate which reduces glucose uptake and utilization
38:39 – how glucose oxidation inhibits the uptake and utilization of fats
45:32 – whether you can “activate” or “deactivate” the Randle cycle
47:22 – glucose oxidation leads to an optimal NAD+/NADH ratio and decreased ROS production
52:08 – the protective effects of CO2 and why the brain can’t use fats as a fuel
53:17 – whether we should strive for metabolic flexibility
55:55 – fat metabolism and ketone production as a mechanism for energy conservation and glucose sparing
1:00:02 – insulin resistance as a state of excess fat metabolism and decreasing fat metabolism or stress hormones improves this state
1:05:28 – should we avoid eating carbs and fats together due to the Randle cycle?
1:08:08 – different cells, tissues, and organs can use different fuels at the same time
