Depth of Anesthesia cover image

33. Do perioperative gabapentinoids decrease postoperative pain?

Depth of Anesthesia

00:00

The Efficacy of Gabapentinoids

The study demonstrated statistically significant decreases in postoperative pain scores for up to 48 hours but these scores did not meet the established minimally important differences of 10 out of 100. A slightly greater probability of analgesic benefit of at least 10 points was seen at 6, 12 and 24 hours but that effect disappeared at 48 and 72. Few patients had an effect greater than 20 and of those that did it was limited to 12 hours and effects greater than 30 were absent. As with any therapy we again need to weigh the potential benefits with the potential harms. Gabapentinoids here were associated with a greater incidence of dizziness with a risk ratio of 1.25 and visual disturbance with a risk ratios of

Play episode from 18:02
Transcript

The AI-powered Podcast Player

Save insights by tapping your headphones, chat with episodes, discover the best highlights - and more!
App store bannerPlay store banner
 Get the app