Clinical TAM, Silent TAM, and Variant Allele Frequency

In this week's episode, we’ll learn more about relationships between Epstein-Barr virus genomic variants and human diseases, including hematological malignancies; the presence and timing of somatic GATA1 mutations and their relationship to a Down syndrome-specific form of leukemia; and new definitions for high-risk multiple myeloma that emphasize the presence of two or more high-risk cytogenetic abnormalities.

Featured Articles:

• Association of Epstein-Barr virus genomic alterations with human pathologies
• Clinical significance of preleukemic somatic GATA1 mutations in children with Down syndrome
• Biallelic antigen escape is a mechanism of resistance to anti-CD38 antibodies in multiple myeloma