The Single Arm Studies and What are the Alternatives?
The Effective Statistician - in association with PSI
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The Advantages of Choosing a First Choice Component for a Randomized Clinical Trial
There is no real, it's a perception that you have to compare yourself to everything out there. The majority of us have one Pico which describes likely our preferred first choice comparator. But for pretty much anybody who does cost utility analysis, the idea is that you need an anchor from which to build onto the other comparators. That's why we want head-to-head comparisons,. We don't like placebo per se.
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