Genetic Factors and Training in Fitness

Dr Glenn McConell chats with Professor José Calbet from the University of Las Palmas de Gran, Canary Islands, Spain. José has a very strong research record and is a global leader in his field. He has done amazing invasive exercise studies in humans to determine the limiting factor(s) to VO2 max. We talked about what is VO2 max, the factors determining VO2 max, the limits to VO2 max, the effects of VO2 max on exercise performance, pseudoanemia, VO2 max in females, VO2 max in masters athletes etc. In general he is finding the oxygen delivery is the main limiting factor to VO2 max. A very interesting, long chat. Twitter: @GRHEFS_ULPGC 0:00. Introduction and how José got into exercise research
4:55. Links with Bengt Saltin and University of Copenhagen
9:12. What is VO2 max?
10:59. Cardiac output and blood pressure
14:15. Blood pressure can drop near VO2 max
15:30. Maximum heart rate/ stroke volume
17:50. Submaximal exercise in trained vs untrained
19:06. Oxygen extraction during exercise
24:40. Main limiting factor to VO2 max
27:41. Capillaries and muscle mitochondria
30:31. Hemoglobin concentration and oxygen delivery
32:40. Athletes limited by oxygen delivery/temptation of EPO
34:35. VO2 max in women: lower hemoglobin
38:19. Pseudoanemia in endurance athletes
45:42. How does high Hb mass improve submax performance?
49:42. Role of genetics and ex training in VO2 max
56:18. Responders and non responded to exercise training?
58:50. Blood flow restraint to maintain blood pressure
1:05:35. Masters athletes vs young untrained
1:12:43. Ex training can slow the decease in max HR with age
1:17:51. Does life long exercise slow the reduction in VO2 max?
1:21:19. Loss of mitochondria with age vs inactivity
1:24:40. David Costill. 70 ml/kg/min VO2 max enough?
1:31:50. Sex differences in metabolism during exercise
1:36:00. How does creatine supplementation reduce VO2 max?
1:37:29. How know how close to VO2 max potential you are at?
1:42:38. Hyperthermia, ventilation and blood flow
1:45:41. Can increase VO2 max by giving vasodilators?
1:48:05. Hypoxia doesn’t increase VO2 max
1:49:44. Takeaway messages
1:50:40. VO2 max and life expectancy
1:53:00. José feels lucky/Bengt Saltin/University of Copenhagen
1:54:32. Outro (9 seconds)
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
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Not medical advice