Over the past few decades, numerous studies have emerged using the promising strategy of bacteria as vehicles to deliver drugs or genes in tumor‐targeted therapies. Researchers say that bacterial cancer therapy may be able to overcome some of the limitations that conventional cancer therapy is stunted by, including the development of drug resistance.
In a 2020 study, researchers—from Yale University, the University of Missouri, Harry S. Truman Memorial Veterans Hospital, Cancer Research Center in Missouri, and DeSales University—investigated a tumor-targeting Salmonella typhimurium strain of bacteria (CRC2631) in prostate cancer-positive mouse-models and evaluated its toxicity, targeting ability and genetic stability. Their trending paper was published by Oncotarget and entitled, “Evaluations of CRC2631 toxicity, tumor colonization, and genetic stability in the TRAMP prostate cancer model.”
“Here, we report the toxicological and in vivo tumor-targeting profiles of CRC2631 in the syngeneic and autochthonous mouse model of aggressive prostate cancer, TRAMP (Transgenic Adenocarcinoma of Mouse Prostate).”
Full blog - https://www.oncotarget.org/2021/01/21/bacterial-therapy-experiments-in-prostate-cancer/
Press release - https://www.oncotarget.com/news/pr/evaluations-in-the-tramp-prostate-cancer-model/
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DOI - https://doi.org/10.18632/oncotarget.27769
Full text - https://www.oncotarget.com/article/27769/text/
Correspondence to - Yves C. Chabu - chabuc@missouri.edu
Keywords - salmonella, cancer targeting, prostate cancer, immunotherapy, TRAMP
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