21: Unleashing Effective QbD Strategies to Master Cell Therapy with Shin Kawamata - Part 1
Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation
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Quality Requirements for Mass Culture of Stem Cells and CAR-T Therapy
Exploring the specific quality requirements for mass culture of stem cells, focusing on maintaining differentiation ability, minimizing mitochondria activation, and highlighting glycolytic pathways for IPSC and MSC. The chapter also discusses the importance of prolonging culture for pharmacological efficacy and maintaining cell quality, as well as the significance of maintaining youth in CAR-T therapy through markers and metabolic considerations.
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