Blocking Orexin and Temptation‑Resistant Exercise

In this episode, we explore how orexin neurons in the brain help us prioritize exercise over tempting distractions like delicious food. Discover the science behind this brain-powered 'gym coach' and learn why some people are better at resisting temptation—giving us fresh insights into motivation, decision-making, and the battle between brain and cravings.

Paper: Tesmer, A. L., Li, X., Bracey, E., Schmandt, C., Polania, R., Peleg-Raibstein, D., & Burdakov, D. (2024). Orexin neurons mediate temptation-resistant voluntary exercise. Nature Neuroscience, 1-9.